Barcelona forward Lionel Messi is likely to miss both legs of the Champions League semi-final because of a thigh muscle tear.
Real Madrid and AC Milan led a procession of six teams into the Champions League last 16 on Wednesday while big-spending Manchester City failed again on the European stage to further dent English soccer's standing.
The result left second-placed Inter on 39 points from 18 matches, 10 points behind Juventus, who beat Palermo 2-1 on Saturday.
Coaches finally put World Cup hopefuls out of their misery on Tuesday when they named their final squads for the tournament, shattering some dreams while also handing out the opportunity of a lifetime.
Serie A leaders Juventus maintained their eight-point cushion at the top of the division with a 2-0 win over Siena on Wednesday.
Real Madrid coach Mourinho surprised many by including Kaka in the starting lineup for Wednesday's 4-1 Champions League win at Ajax and he responded with a performance full of verve and creativity that suggests he may be working his way back into contention.
Cristiano Ronaldo hit a hat-trick in Real Madrid's 4-1 Champions League win at Ajax Amsterdam on Wednesday but big spending trio Zenit St Petersburg, Paris St Germain and Manchester City failed to win.
Zlatan Ibrahimovic will become the first player since Jean-Pierre Papin to score at least 30 goals in a French league season, the former France striker predicted on Tuesday.
Italy striker Antonio Cassano has confirmed he is a major doubt for Euro 2012, saying he needs six months to return to action after undergoing emergency heart surgery in November.
A summary of football matches played across Europe over the weekend.
Holders Barcelona will play Bayer Leverkusen, a team famous for fading in the final straight, while their arch-rivals Real Madrid face a trip to icy Moscow in the Champions League round of 16 following the draw on Friday. Bayern Munich, whose Allianz Arena will host the final, take on FC Basel, the underdogs who spectacularly ousted Manchester United, in another of the top ties.
Gennaro Gattuso faces the prospect of disciplinary action for his headbutt on Tottenham Hotspur assistant coach Joe Jordan after UEFA said on Wednesday it was opening a case against the AC Milan captain.
Argentina striker Hernan Crespo, who spent last season on loan at AC Milan, is to resume his career at Chelsea
Brazil winger Ronaldinho has become the central figure in the latest embarrassment to befall Blackburn Rovers' Indian owners, Venky's, following a Twitter post suggesting that they had offered the AC Milan ace a six million a year deal.
The Englishman lasted 31 games, winning only 12, before the owners pulled the trigger.
Juventus moved one win away from the Serie A title after they beat Parma 2-0 while AC Milan were held 2-2 at Lecce.
After Manchester took top billing in the Champions league on Tuesday it was London's turn on Wednesday when Chelsea and Arsenal recorded impressive, though contrasting, victories as the Premier League again flexed its muscles.
Midfielder Riccardo Montolivo missed out on his second straight major tournament due to injury on Tuesday while Daniele De Rossi was included in Italy's 23-man squad for next month's European Championship in France.
Former France World Cup winner Marcel Desailly is among the candidates to become new Ghana coach, the Black Stars said on their website (www.ghanafa.org) on Monday.
The French side moved to the brink of the Champions League quarter-finals with a ruthless 3-0 victory over Werder Bremen.
Not even 100 metres world record holder Usain Bolt could have caught AC Milan's Alexandre Pato when he streaked through to score against Barcelona after 24 seconds on Tuesday, Barca coach Pep Guardiola said.
A round-up of action in Europe's main leagues over the weekend.
Real Madrid won the Club World Cup for a record extending fifth time after beating Saudi Arabia's Al Hilal 5-3 in the final on Saturday.
Cristiano Ronaldo delivered the knockout blow for Real Madrid in their aristocratic battle with AC Milan on Tuesday, as Arsenal, Chelsea and Bayern Munich maintained their own perfect Champions League starts.
Juventus produced a stunning performance to beat holders Real Madrid 3-1 in their Champions League semi-final second leg and advanced to the final.
A summary of Sunday's action in Serie A and Bundesliga.
Last season's runners-up suffered a 3-1 defeat to Newcastle United in the Champions League.
They scored their 11th successive Champions League win with a 3-0 victory over Inter Milan.
Barcelona's Lionel Messi set a Champions League scoring record when he took his tally to 14 in the competition so far this season as the holders knocked out AC Milan to reach the semi-finals on Tuesday.
Lionel Messi led Barcelona almost effortlessly past AC Milan into the Champions League semi-finals on Tuesday with a thrilling 3-1 victory at the Nou Camp as the Argentine and his team mates got into the record books along the way.
Arsenal manager Arsene Wenger's has been given a three-match ban and fined 40,000 euros for confronting match officials after his side's Champions League exit against AC Milan this month.
Barcelona and Manchester United clash in the Champions League final at Wembley on Saturday (1845 GMT) to decide who are the undisputed kings of Europe.
Juventus missed the chance to return to the top of Serie A when they were held to a 0-0 draw at mid-table Parma on Wednesday.
Thierry Henry, Arsenal's all-time leading scorer, will return to New York Red Bulls next week as his loan spell cannot be extended past the agreed date, Arsenal manager Arsene Wenger said.
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